General Cell Based Assays
Cayman Chemical Cyclohexnoyl-Coenzyme A 1mg
An acyl-CoA that contains a cyclohexane group; formed through conversion of CHC by a succinyl-CoA transferase, and degraded by a dehydrogenase; converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver
Cayman Chemical MPO asy Buffer1X 1ea
A - and K1-opioid receptor antagonist (Kis 0.3 and 0.2 nM respectively) selective for - and K1-opioid receptors over the -opioid receptor (Ki 12.8 nM) reversibly inhibits electricity-induced twitches of isolated guinea pig ileal longitudinal muscle strips (IC50 48 nM) indicating opioid agonist activity inhibits endomorphin 1-induced conditioned place preference in mice at 0.3 UG/animal i.c.v. prevents decreases in urine output induced by fentanyl D-propoxyphene buprenorphine profadol or bromadoline in water-loaded rats at 40 mg/kg reduces hemokinin 1-induced increases in the latency to withdrawal in the tail-flick test in mice
Eurofins Discoverx SPRINTer™ Human c-Myc Targeted Protein Degradation Cell-Based Assay Kit (K562)
The SPRINTer™ Human c-Myc Targeted Protein Degradation Stable Cell Line Assay (K562) contains a stable clonal cell line used for monitoring drug-induced protein turnover of c-Myc, supporting TPD studies. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human CXCL16 (CXCR6) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human CXCL16 (CXCR6) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure CXCR6 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx SPRINTer™ Human IKZF2 Targeted Protein Degradation Cell-Based Assay Kit (Jurkat)
The SPRINTer™ Human IKZF2 Targeted Protein Degradation Stable Cell Line Assay (Jurkat) contains a stable clonal cell line used for monitoring drug-induced protein turnover of IKZF2, supporting TPD studies. This is a complete kit that includes the cell line vials, all required culture reagents for maintaining the cells in continuous culture, and detection reagents for running the assay.
Eurofins Discoverx PathHunter Human CFTR-ΔF508 MEM-EA Pharmacotrafficking Cell-Based Assay Kit (U2OS)
The PathHunter Human CFTR-ΔF508 MEM-EA Pharmacotrafficking Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure pharmacochaperone-based rescue of the mutant CFTR's trafficking to the membrane. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human F2RL1 β-Arrestin Cell-Based Assay Kit (U2OS)
The PathHunter Human F2RL1 β-Arrestin Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure F2RL1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter™ Human ADCYAP1R1 (PAC1) Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human ADCYAP1R1 (PAC1) Gs Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure ADCYAP1R1 (GPCR) activity via increased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Meso Scale Discovery U-PLEX Mouse TNF- ASY
The Meso Scale Discovery U-PLEX Mouse TNF-alpha Assay is a multiplex immunoassay kit that enables simultaneous measurement of mouse tumor necrosis factor alpha (TNF-alpha) in serum plasma and cell culture supernatants It utilizes electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This assay requires 50 L or less sample volume and can be fully automated on the MSD instrument platforms The lower limit of detection is 0 04 pg/mL
Eurofins Discoverx PathHunter Human Syk Kinase Activity Cell-Based Assay Kit (U2OS)
The PathHunter Human Syk Stable Cell Line Kinase Activity Assay (U2OS) measures SYK CTK activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human AVPR1B β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human AVPR1B β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure AVPR1B (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human FFAR1 (GPR40) β-Arrestin-1 Cell-Based Assay Kit (HEK 293)
The PathHunter Human FFAR1 (GPR40) β-Arrestin-1 Stable Cell Line Assay (HEK 293) contains a stable clonal cell line used to measure FFAR1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter™ Human ADRB1 Gs Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human ADRB1 Gs Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure ADRB1 (GPCR) activity via increased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human GPR120 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human GPR120 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GPR120L (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress AVPR2 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0588E2CP0M)
The PathHunter AVPR2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. vasopressin) based activation of AVPR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AVPR2 and EA-tagged β-Arrestin-2. Activation of AVPR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.